20S Proteasome Test Your Knowledge

Test Your Knowledge

Quiz: Is This Triplet Regimen Safe to Treat R/R MM?

02/03/2022

True or false: Ixazomib with pomalidomide plus dexamethasone cannot be combined safely.

True or false: Ixazomib with...

02/03/2022

Oncology

Test Your Knowledge

Quiz: What Type of Ixazomib Combo Shows Improved Responses for Patients With MM?

12/09/2021

True or false: Triplet combinations including ixazomib for patients with MM have shown more efficacious results than doublet regimens in the relapse setting.

True or false: Triplet...

12/09/2021

Oncology

Test Your Knowledge

Quiz: What is the Role of the Ubiquitin-Proteasome System in Protein Degradation?

11/16/2021

Which of the following does the ubiquitin-proteasome system regulate?

Which of the following does the...

11/16/2021

Oncology

Test Your Knowledge

Quiz: Which Bladder Cancer Type Shows Elevated Concentrations of 20S Proteasome?

10/28/2021

Which of the following types of bladder cancer shows significantly elevated concentrations of both the 20S proteasome and UCH-L1?

Which of the following types of...

10/28/2021

Oncology

Quiz

Quiz: What is the Role of 20S Proteasome Molecules in MM?

09/29/2021

True or false: 20S proteasome molecules exhibit activity in MM.

True or false: 20S proteasome...

09/29/2021

Oncology

Quiz

Quiz: The Effects of P53 Levels in 20S Proteasome Functionality

08/03/2021

True or false: When the 20S proteasome is not functioning correctly, there is a decrease in p53 levels, which can induce mutated forms of p53, and ultimately lead to a variety of cancers.

True or false: When the 20S...

08/03/2021

Oncology

Test Your Knowledge

Quiz: The 2 Most Common MM Treatment Regimens

11/17/2020

The 2 most common treatment regimens administered to patients with MM are an RvD-like regimen and the combination of daratumumab, lenalidomide, and __________.

The 2 most common treatment...

11/17/2020

Oncology

Test Your Knowledge

Quiz: What Was the Purpose of the KarMMa Clinical Trial?

11/11/2020

True or False: In the KarMMA clinical trial, investigators looked at the use of anti-BCMA CAR-T therapy for relapsed/refractory MM.

True or False: In the KarMMA...

11/11/2020

Oncology

Test Your Knowledge

Quiz: Which Adverse Event is Most Common With Combo CAR-T Therapy for R/R MM?

09/03/2020

In a study by Dr Yan et al, the most common AE observed with the infusion of humanized anti-CD19 and anti-BCMA CAR T-cells in patients with relapsed or refractory MM was which of the following?

In a study by Dr Yan et al, the...

09/03/2020

Oncology

Test Your Knowledge

Quiz: Possible Correlation Between Disparities in MM Prognosis and Sociodemographic Factors?

08/25/2020

True or False: Findings suggest that a correlation may exist between low education levels and poor survival in patients with multiple myeloma in China.

True or False: Findings suggest...

08/25/2020

Oncology

Recent News

News

Osimertinib Lacks Activity in Neoadjuvant Setting for Early-Stage Non-Small Cell Lung Cancer With EGFR Mutation

08/08/2024

Stephanie Holland ;

Results from a phase 2 study demonstrated that neoadjuvant osimertinib did not improve the major pathological response rate among patients with early-stage non-small cell lung cancer harboring an EGFR mutation.

Results from a phase 2 study...

08/08/2024

Oncology

FDA Approval

FDA Approves Denileukin Diftitox for Patients With R/R Cutaneous T-Cell Lymphoma

08/08/2024

Amber Denham ;

The US Food and Drug Administration approved novel immunotherapy denileukin diftitox-cxdl for the treatment of patients with relapsed/refractory cutaneous T-cell lymphoma after at least 1 prior systemic therapy.

The US Food and Drug...

08/08/2024

Oncology

News

Tailored Dose-Dense Chemotherapy Improved Survival Outcomes Among Patients With High-Risk Early Breast Cancer

08/07/2024

Stephanie Holland ;

According to results from the phase 3 PANTHER trial, tailored and dose-dense chemotherapy in the adjuvant setting improved survival outcomes compared to standard chemotherapy among patients with high-risk early breast cancer.

According to results from the...

08/07/2024

Oncology

News

Frontline Treatment Management for Patients With FL Reduces Risk of High-Grade Transformation to DLBCL

08/07/2024

Amber Denham ;

A recent study demonstrated that frontline treatment management reduced the risk of high-grade transformation to diffuse large B-cell lymphoma among patients with follicular lymphoma, but not among patients with marginal zone lymphoma.

A recent study demonstrated that...

08/07/2024

Oncology

News

Optimal Sotorasib Dose for Patients With KRAS G12C-Mutated Advanced Non-Small Cell Lung Cancer

08/07/2024

Stephanie Holland ;

Results from a phase 2 study found that 960 mg of sotorasib is preferable to 240 mg among patients with previously treated KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer.

Results from a phase 2 study...

08/07/2024

Oncology

FDA Approval

FDA Approves Vorasidenib for Patients With IDH1/IDH2-Mutated Grade 2 Astrocytoma or Oligodendroglioma

08/06/2024

Stephanie Holland ;

Based on results from the INDIGO trial, the FDA has approved vorasidenib for adult and pediatric patients 12 years and older with grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation following surgery.

Based on results from the INDIGO...

08/06/2024

Oncology

FDA Approval

FDA Approves Afamitresgene Autoleucel for Certain Unresectable or Metastatic Synovial Sarcoma

08/02/2024

Allison Casey ;

On August 2, 2024, the US Food and Drug Administration (FDA) granted accelerated approval to afamitresgene autoleucel for the treatment of adult patients with certain unresectable or metastatic synovial sarcomas who had received prior...

On August 2, 2024, the US Food...

08/02/2024

Oncology

FDA Approval

FDA Approves Dostarlimab Plus Chemotherapy for Patients With Primary Advanced or Recurrent Endometrial Cancer

08/01/2024

Allison Casey ;

The FDA approved dostarlimab plus carboplatin and paclitaxel, followed by single-agent dostarlimab for patients with primary advanced or recurrent endometrial cancer.

The FDA approved dostarlimab...

08/01/2024

Oncology

News

Iadademstat and Azacitidine Combination Therapy Demonstrates Manageable Safety, Promising Efficacy for Patients With Newly Diagnosed AML

08/01/2024

Amber Denham ;

The first-line combination of iadademstat and azacitidine demonstrates a manageable safety profile and promising results among patients with acute myeloid leukemia, according to phase 2 results from the ALICE trial.

The first-line combination of...

08/01/2024

Oncology

News

Effect of Food on Selumetinib Dosing for Adolescent Patients With Neurofibromatosis Type 1 With Plexiform Neurofibromas

08/01/2024

Allison Casey ;

In the phase 1 trial, the addition of a low-fat meal with doses of selumetinib did not significantly impact selumetinib exposure or gastrointestinal toxicities among adolescent patients with neurofibromatosis type 1 with plexiform...

In the phase 1 trial, the...

08/01/2024

Oncology